(Music) At least thirty years of research here at
SDSU in my lab, where we’ve been studying how the heart responds to stress. So we look inside the cells of the heart and
we look for bio-chemical processes that respond to those stresses and we’ve found such a process in one
particular molecule that we abbreviate ATF-6. What we sought was a way to restore ATF-6,
either in the diseased heart, or in the aged heart and know we know we have a way to do that. And that’s what this grant was about, is pursuing
this way to restore ATF-6 activity in the heart. I was the lead scientist for the drug development
project where we’re looking at a small molecule that can mitigate infarct size during a heart attack. And now we’re looking forward to taking that
a little bit further and developing the drug. Each year one out of every four people dies
of cardiovascular disease in the country. That’s six hundred thousand people per year.
And so we’re hoping to make a difference there and maybe cut that number down. At SDSU and particularly the SDSU Heart Institute,
students are a big part of our research enterprise. They really make our institute what it is today. All of the data that went into the proposal
was generated by two of my students. It was viewed by the review panel as so compelling,
they gave the grant a perfect score. It came about by a lot of work by a lot of people. Including our boss, Chris Glembotski, and
a lot of the people on the team that worked on this project. A lot of hours went into this project and
a lot of thorough planning prior to it. That led to what seemed to be a seamless perfect
score and we’re very happy about it. The compound that we found, which we think is
a drug candidate, decreases the damage to the heart during a heart attack. And that would
translate, if we make this into a drug, to increased lives saved as a result of this. And so, basically a new treatment for heart
disease after a heart attack. And I never thought that I would have the
opportunity to do research like this that could have such a great impact. So, for me and for others who come in and
have the same kind of background, that’s really important that we can actually make a difference and that’s pretty exciting. You have a to have a well-written product,
the proposal itself. And it’s got to be compelling, novel, innovative
and potentially result in a therapy in the future. The other thing that’s necessary is, it has
to be done at a research institute capable of doing the highest level, in this case heart
research, in the world. And I’m very proud that SDSU Heart Institute
meets these requirements. (Music)